BDBM50336881 2-morpholino-N6-(6-phenoxypyridin-3-yl)-4,5'-bipyrimidine-2',6-diamine::CHEMBL1672326

SMILES Nc1ncc(cn1)-c1cc(Nc2ccc(Oc3ccccc3)nc2)nc(n1)N1CCOCC1

InChI Key InChIKey=JCCMMGYLXXXXQO-UHFFFAOYSA-N

Data  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50336881   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50336881(2-morpholino-N6-(6-phenoxypyridin-3-yl)-4,5'-bipyr...)Copy SMILESCopy InChI

Affinity DataEC50:  110nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI