BDBM50336981 CHEMBL1672629::N-[5-(3,5-Difluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropane carboxamide

SMILES Fc1cncc(F)c1-c1ncc(NC(=O)C2CC2)nc1-c1cccnc1

InChI Key InChIKey=JSTVKVBTXCGTLN-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50336981   

TargetAdenosine receptor A2b(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336981(CHEMBL1672629 | N-[5-(3,5-Difluoropyridin-4-yl)-6-...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336981(CHEMBL1672629 | N-[5-(3,5-Difluoropyridin-4-yl)-6-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336981(CHEMBL1672629 | N-[5-(3,5-Difluoropyridin-4-yl)-6-...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336981(CHEMBL1672629 | N-[5-(3,5-Difluoropyridin-4-yl)-6-...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336981(CHEMBL1672629 | N-[5-(3,5-Difluoropyridin-4-yl)-6-...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed