BDBM50337134 2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one::CHEMBL1673046::Scaffold, B46::US9266890, IV-6

SMILES: CCOc1cc(ccc1Nc2ncc3c(n2)N(c4ccccc4C(=O)N3C)C)N5CCC(CC5)O

InChI Key: InChIKey=QAPAJIZPZGWAND-UHFFFAOYSA-N

Data: 7 IC50  9 Kd

PDB links: 3 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 233 hits for monomerid = 50337134   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 7 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 7 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 7 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 7 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Bromodomain-containing protein 4 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase DCLK1 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	716	n/a	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	205	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	735	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bromodomain testis-specific protein (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bromodomain testis-specific protein (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	675	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bromodomain testis-specific protein (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 7 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 7 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 7 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Ribosomal protein S6 kinase alpha-1 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4-kinase beta (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Phosphatidylinositol 4-kinase alpha (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Ribosomal protein S6 kinase alpha-3 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Acylglycerol kinase, mitochondrial (Homo sapiens)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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RAC-alpha serine/threonine-protein kinase (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase A-Raf (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase ATR (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Aurora kinase A (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase B-raf (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Calcium/calmodulin-dependent protein kinase type 1D (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Calcium/calmodulin-dependent protein kinase type II subunit delta (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Calcium/calmodulin-dependent protein kinase type II subunit gamma (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 10 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Cyclin-dependent kinase 2 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Cyclin-dependent kinase 5 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 7 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Cyclin-dependent kinase 9 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 13 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase Chk1 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Casein kinase I isoform alpha (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase CSK (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Eukaryotic elongation factor 2 kinase (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 2 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Ephrin type-B receptor 4 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase 3 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase 1 (Human)	BDBM50337134 (US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair