BDBM50337139 11-ethyl-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one::CHEMBL1673051

SMILES CCN1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc12

InChI Key InChIKey=JGVXSQJYBQAPAE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50337139   

TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337139(11-ethyl-2-((2-methoxy-4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337139(11-ethyl-2-((2-methoxy-4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50:  66nMAssay Description:Inhibition of ERK5 in human HeLa cells assessed as reduction in EGF-induced ERK5 autophosphorylation pretreated for 1 hr followed by EGF stimulation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337139(11-ethyl-2-((2-methoxy-4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50:  57nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase DCLK1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337139(11-ethyl-2-((2-methoxy-4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50:  154nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DCLK1 (G351 to H689 residues) expressed in Escherichia coli BL21 DE3 using 5-FAM-KKLRRTLSVA-CO...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed