BDBM50337315 5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-amine::CHEMBL1682346::US9163007, 62

SMILES Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1

InChI Key InChIKey=VBNPWXWJZJNXEY-UHFFFAOYSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50337315   

TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM50337315(5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...)
Affinity DataKi:  12nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337315(5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...)
Affinity DataKi:  64nMAssay Description:Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337315(5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...)
Affinity DataKi:  91nMAssay Description:Inhibition of JAK2 after 1 hr using biotinylated PDKtide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337315(5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...)
Affinity DataKi:  252nMAssay Description:Inhibition of Aurora kinase 2 after 1 hr using biotinylated kemptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337315(5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...)
Affinity DataKi:  265nMAssay Description:Inhibition of GSK3-beta after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337315(5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...)
Affinity DataKi: >1.80E+3nMAssay Description:Inhibition of EGFR after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337315(5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...)
Affinity DataKi: >3.75E+3nMAssay Description:Inhibition of Pak4 after 1 hr using biotinylated L15 peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337315(5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...)
Affinity DataKi:  3.98E+3nMAssay Description:Inhibition of KDR after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337315(5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...)
Affinity DataKi: >8.57E+3nMAssay Description:Inhibition of Pim1 after 1 hr using biotinylated AL1peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed