BDBM50338313 (+/-)-3-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-5-yl)acrylonitrile::CHEMBL1682428
SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=C\C#N)c12)-c1cccc2cc[nH]c12
InChI Key InChIKey=FEMGRFJEGDQZBL-XQTZDJHXSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50338313
Affinity DataKi: 16.6nMAssay Description:Displacement of radiolabeled dexamethasone from GRMore data for this Ligand-Target Pair
Affinity DataEC50: 5.70nMAssay Description:Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasoneMore data for this Ligand-Target Pair
Affinity DataIC50: 6.5nMAssay Description:Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...More data for this Ligand-Target Pair