BDBM50339750 (S)-2-(4-chloro-2-((3-methyl-4-(phenylsulfonyl)piperazin-1-yl)methyl)phenoxy)acetic acid::CHEMBL1689119

SMILES C[C@H]1CN(Cc2cc(Cl)ccc2OCC(O)=O)CCN1S(=O)(=O)c1ccccc1

InChI Key InChIKey=OVNWHOGUZJEKAS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50339750   

TargetProstaglandin D2 receptor 2(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50339750((S)-2-(4-chloro-2-((3-methyl-4-(phenylsulfonyl)pip...)
Affinity DataIC50: 0.800nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50339750((S)-2-(4-chloro-2-((3-methyl-4-(phenylsulfonyl)pip...)
Affinity DataIC50: 4.5nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50339750((S)-2-(4-chloro-2-((3-methyl-4-(phenylsulfonyl)pip...)
Affinity DataIC50: 16nMAssay Description:Antagonist activity against human CRTh2 receptor expressed in CHO cells assessed as inhibition of PGD2-mediated Ca2+ fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50339750((S)-2-(4-chloro-2-((3-methyl-4-(phenylsulfonyl)pip...)
Affinity DataIC50: 31nMAssay Description:Antagonist activity against human CRTh2 receptor expressed in CHO cells assessed as inhibition of PGD2-mediated Ca2+ fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed