BDBM50340484 (5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifluoromethyl)sulfonyl]phenyl}imidazolidine-2,4-dione::(S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidine-2,4-dione::CHEMBL1738841::CHEMBL1762153

SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12

InChI Key InChIKey=PLSQYACXDKUYFC-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50340484   

TargetInsulin receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 300nMAssay Description:Inhibition of insulin receptor kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 300nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 500nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 600nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 700nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed