BDBM50340566 CHEMBL1762535::N2-(3,5-dimorpholinophenyl)-N4-(5-methoxypyridin-3-yl)-N4-methylpyrimidine-2,4-diamine

SMILES COc1cncc(c1)N(C)c1ccnc(Nc2cc(cc(c2)N2CCOCC2)N2CCOCC2)n1

InChI Key InChIKey=DLGLTPBGHQDZCX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50340566   

TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340566(CHEMBL1762535 | N2-(3,5-dimorpholinophenyl)-N4-(5-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340566(CHEMBL1762535 | N2-(3,5-dimorpholinophenyl)-N4-(5-...)
Affinity DataIC50:  140nMAssay Description:Inhibition FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340566(CHEMBL1762535 | N2-(3,5-dimorpholinophenyl)-N4-(5-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human EPHB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340566(CHEMBL1762535 | N2-(3,5-dimorpholinophenyl)-N4-(5-...)
Affinity DataIC50:  430nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed