BDBM50340676 CHEMBL1762225::exo-(S)-5-fluoro-4-hydroxy-1-(3-methylene-3,6-dihydro-2H-pyran-2-yl)pyrimidin-2(1H)-one

SMILES Fc1cn([C@H]2OCC=CC2=C)c(=O)[nH]c1=O

InChI Key InChIKey=VZTRXSLJCSNNPV-VIFPVBQESA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50340676   

TargetThymidylate synthase(Mus musculus)
University Of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340676(CHEMBL1762225 | exo-(S)-5-fluoro-4-hydroxy-1-(3-me...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
University Of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340676(CHEMBL1762225 | exo-(S)-5-fluoro-4-hydroxy-1-(3-me...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 4 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
University Of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340676(CHEMBL1762225 | exo-(S)-5-fluoro-4-hydroxy-1-(3-me...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 24...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
University Of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340676(CHEMBL1762225 | exo-(S)-5-fluoro-4-hydroxy-1-(3-me...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
University Of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340676(CHEMBL1762225 | exo-(S)-5-fluoro-4-hydroxy-1-(3-me...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 4 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
University Of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340676(CHEMBL1762225 | exo-(S)-5-fluoro-4-hydroxy-1-(3-me...)
Affinity DataIC50:  430nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 24 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed