BDBM50341218 1-(4-fluoro-3-(trifluoromethyl)phenyl)-9-(1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2(1H)-one::CHEMBL1765603

SMILES Fc1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cn[nH]c1

InChI Key InChIKey=WNLUSIMLVLXZKS-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50341218   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50341218(1-(4-fluoro-3-(trifluoromethyl)phenyl)-9-(1H-pyraz...)
Affinity DataEC50: >1.25E+3nMAssay Description:Inhibition of PI3Kalpha in human PC3 cells expressing Akt1 S473D mutant assessed as phosphorylation of Akt Thr308 by immunoblottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50341218(1-(4-fluoro-3-(trifluoromethyl)phenyl)-9-(1H-pyraz...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed