BDBM50341243 (3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide::CHEMBL1765740

SMILES: CNc1nc(cc(n1)-c1ccc2c(N)n[nH]c2c1)N1C[C@H](CC[C@H]1C)C(=O)NC1CCCCC1

InChI Key: InChIKey=QLPHOXTXAKOFMU-UHFFFAOYSA-N

Data: 22 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50341243   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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3-phosphoinositide-dependent protein kinase 1 (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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Rho-associated protein kinase 1 (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
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TGF-beta receptor type-1 (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase A (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase SYK (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
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[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 5 (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
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RAC-alpha serine/threonine-protein kinase (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	113	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	293	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit alpha (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50341243 ((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair