BDBM50341253 5-(3-chlorobenzylidene)-2-p-tolylthiazol-4(5H)-one::CHEMBL1765884

SMILES Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\c1cccc(Cl)c1

InChI Key InChIKey=HDAMYDZDGGOCEE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341253   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50341253(5-(3-chlorobenzylidene)-2-p-tolylthiazol-4(5H)-one...)
Affinity DataIC50: 300nMAssay Description:Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50341253(5-(3-chlorobenzylidene)-2-p-tolylthiazol-4(5H)-one...)
Affinity DataIC50: 300nMAssay Description:Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50341253(5-(3-chlorobenzylidene)-2-p-tolylthiazol-4(5H)-one...)
Affinity DataIC50: 580nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50341253(5-(3-chlorobenzylidene)-2-p-tolylthiazol-4(5H)-one...)
Affinity DataIC50: 580nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed