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BDBM50341490 CHEMBL1765460::N-(5-(Imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)benzenesulfonamide

SMILES: O=S(=O)(Nc1cncc(c1)-c1ccc2nccn2c1)c1ccccc1

InChI Key: InChIKey=IEBWNBIVIFQUPF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50341490   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50341490
PNG
(CHEMBL1765460 | N-(5-(Imidazo[1,2-a]pyridin-6-yl)p...)
Show SMILES O=S(=O)(Nc1cncc(c1)-c1ccc2nccn2c1)c1ccccc1
Show InChI InChI=1S/C18H14N4O2S/c23-25(24,17-4-2-1-3-5-17)21-16-10-15(11-19-12-16)14-6-7-18-20-8-9-22(18)13-14/h1-13,21H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 360n/an/an/an/an/an/a



Korea Advanced Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha after 180 mins by luminescent assay


J Med Chem 54: 2455-66 (2011)


Article DOI: 10.1021/jm101582z
BindingDB Entry DOI: 10.7270/Q2ZP46F1
More data for this
Ligand-Target Pair