BDBM50341782 4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]phenyl}piperidine-1-carbonyl)-trans-cyclohexanecarboxylic Acid::CHEMBL1766811

SMILES OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(CC1)c1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cc1

InChI Key InChIKey=MARFUFVBECBSBC-HZCBDIJESA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50341782   

TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Vit University

Curated by ChEMBL
LigandPNGBDBM50341782(4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carb...)
Affinity DataIC50:  114nMAssay Description:Inhibition of human DGAT1 using 1,2-diacylglycerol/[14C]-oleoyl CoA as substrate assessed as [14C]-triglyceride formation after 10 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Vit University

Curated by ChEMBL
LigandPNGBDBM50341782(4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carb...)
Affinity DataEC50:  493nMAssay Description:Inhibition of human DGAT1 expressed in CHO-K1 cells after 1 hr using palmitoyl-1-14C-coenzyme A by phospholipid flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Vit University

Curated by ChEMBL
LigandPNGBDBM50341782(4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carb...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected insect cells after 1 hr using palmitoyl-1-14C-coenzyme A by phospholipid flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341782(4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carb...)
Affinity DataIC50:  6.84E+4nMAssay Description:Inhibition of human ACAT2 expressed in human HepG2 cells after incubated with compound for 15 mins measured after 1 hr using palmitoyl-1-14C-coenzyme...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341782(4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carb...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DGAT2 expressed in baculovirus infected Sf9 cells using palmitoyl-1-14C-coenzyme A by TLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341782(4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carb...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341782(4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carb...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341782(4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carb...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341782(4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carb...)
Affinity DataIC50:  6.84E+4nMAssay Description:Inhibition of human ACAT1 expressed in human HepG2 cells after incubated with compound for 15 mins measured after 1 hr using palmitoyl-1-14C-coenzyme...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341782(4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carb...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed