BDBM8960 (+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one::2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one::Aricept::Aricept odt::CHEMBL1678::CHEMBL2337271::CHEMBL502::DONEPEZIL HYDROCHLORIDE::Donepezil::Donepzil::E2020::US8999994, Donepezil::US9346818, DPH::US9586925, Donepezil::US9663465, Donepezil

SMILES: COc1cc2c(cc1OC)C(=O)[C@@H](C2)CC3CCN(CC3)Cc4ccccc4

InChI Key: InChIKey=ADEBPBSSDYVVLD-UHFFFAOYSA-N

Data: 24 KI  675 IC50  1 Kd  1 EC50

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 700 hits for monomerid = 8960   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acetylcholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Bovine)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	8.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	930	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.42E+3	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	23	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.87E+3	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.70	n/a	n/a	n/a	n/a	8.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	8.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] A (Rat)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.55E+8	n/a	n/a	n/a	n/a	7.4	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Rat)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.54E+7	n/a	n/a	n/a	n/a	7.4	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.41E+3	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	8.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.41E+3	n/a	n/a	n/a	n/a	8.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60	n/a	n/a	n/a	n/a	8.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	8.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	8.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] A (Rat)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.28E+5	n/a	n/a	n/a	n/a	7.4	38
TBA									Citation and Details
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Rat)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.75E+4	n/a	n/a	n/a	n/a	7.4	38
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Rat)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.94E+3	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.16	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	8.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	8.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Mouse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	8.0	2
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.52E+3	n/a	n/a	n/a	n/a	8.0	2
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	54	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
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Bile salt export pump (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.46E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Horse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Mouse)	BDBM8960 (2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair