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BDBM50342476 (S)-cyclobutyl(3-(3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone::CHEMBL1771623

SMILES: COc1cccc(c1)-c1noc(n1)[C@H]1CCCN(C1)C(=O)C1CCC1

InChI Key: InChIKey=KIVCLWIXIFBBDX-HNNXBMFYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50342476   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50342476
PNG
((S)-cyclobutyl(3-(3-(3-methoxyphenyl)-1,2,4-oxadia...)
Show SMILES COc1cccc(c1)-c1noc(n1)[C@H]1CCCN(C1)C(=O)C1CCC1
Show InChI InChI=1S/C19H23N3O3/c1-24-16-9-3-7-14(11-16)17-20-18(25-21-17)15-8-4-10-22(12-15)19(23)13-5-2-6-13/h3,7,9,11,13,15H,2,4-6,8,10,12H2,1H3/t15-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulator activity at mGluR5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium flux preincu...


Bioorg Med Chem Lett 21: 2711-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.119
BindingDB Entry DOI: 10.7270/Q21C1X6Z
More data for this
Ligand-Target Pair