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BDBM50342643 6-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline::CHEMBL1770746

SMILES: FC(F)(F)c1cccc(c1)-c1ccc2CNCCc2c1

InChI Key: InChIKey=XQPGJRYJIUWYCG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50342643   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive cation channel 3


(Homo sapiens (Human))
BDBM50342643
PNG
(6-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydrois...)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C16H14F3N/c17-16(18,19)15-3-1-2-11(9-15)12-4-5-14-10-20-7-6-13(14)8-12/h1-5,8-9,20H,6-7,10H2
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PC sid
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Similars

Article
PubMed
n/an/a 7.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.115
BindingDB Entry DOI: 10.7270/Q2QV3MVJ
More data for this
Ligand-Target Pair