BDBM50342989 CHEMBL1771000::N4-isobutyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine

SMILES CC(C)CNc1cc(nc(N)n1)N1CCN(C)CC1

InChI Key InChIKey=LJUOJSBZZTZROX-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50342989   

TargetHistamine H4 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50342989(CHEMBL1771000 | N4-isobutyl-6-(4-methylpiperazin-1...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50342989(CHEMBL1771000 | N4-isobutyl-6-(4-methylpiperazin-1...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50342989(CHEMBL1771000 | N4-isobutyl-6-(4-methylpiperazin-1...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed