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BDBM50342992 (R)-N4-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine::CHEMBL1770977

SMILES: CN[C@@H]1CCN(C1)c1cc(NC(C)C)nc(N)n1

InChI Key: InChIKey=XOJGZLKPRQBGOK-SECBINFHSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50342992   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (human))
BDBM50342992
PNG
((R)-N4-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NC(C)C)nc(N)n1
Show InChI InChI=1S/C12H22N6/c1-8(2)15-10-6-11(17-12(13)16-10)18-5-4-9(7-18)14-3/h6,8-9,14H,4-5,7H2,1-3H3,(H3,13,15,16,17)/t9-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM50342992
PNG
((R)-N4-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NC(C)C)nc(N)n1
Show InChI InChI=1S/C12H22N6/c1-8(2)15-10-6-11(17-12(13)16-10)18-5-4-9(7-18)14-3/h6,8-9,14H,4-5,7H2,1-3H3,(H3,13,15,16,17)/t9-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair