BindingDB logo
myBDB logout

BDBM50343016 CHEMBL1770966::N2-cyclopentyl-4-(4-methylpiperazin-1-yl)pyridine-2,6-diamine

SMILES: CN1CCN(CC1)c1cc(N)nc(NC2CCCC2)c1

InChI Key: InChIKey=KCEDEBUAOPDHGT-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50343016   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50343016
PNG
(CHEMBL1770966 | N2-cyclopentyl-4-(4-methylpiperazi...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(NC2CCCC2)c1
Show InChI InChI=1S/C15H25N5/c1-19-6-8-20(9-7-19)13-10-14(16)18-15(11-13)17-12-4-2-3-5-12/h10-12H,2-9H2,1H3,(H3,16,17,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50343016
PNG
(CHEMBL1770966 | N2-cyclopentyl-4-(4-methylpiperazi...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(NC2CCCC2)c1
Show InChI InChI=1S/C15H25N5/c1-19-6-8-20(9-7-19)13-10-14(16)18-15(11-13)17-12-4-2-3-5-12/h10-12H,2-9H2,1H3,(H3,16,17,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair