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BDBM50343185 2-(1-(2-fluoro-3-(1H-pyrazol-4-yl)benzyl)-1H-indol-3-ylsulfonyl)-N-(5-methylisoxazol-3-yl)acetamide::CHEMBL1773114

SMILES: Cc1cc(NC(=O)CS(=O)(=O)c2cn(Cc3cccc(-c4cn[nH]c4)c3F)c3ccccc23)no1

InChI Key: InChIKey=TWEUJZGNUBCVFU-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50343185   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50343185
PNG
(2-(1-(2-fluoro-3-(1H-pyrazol-4-yl)benzyl)-1H-indol...)
Show SMILES Cc1cc(NC(=O)CS(=O)(=O)c2cn(Cc3cccc(-c4cn[nH]c4)c3F)c3ccccc23)no1
Show InChI InChI=1S/C24H20FN5O4S/c1-15-9-22(29-34-15)28-23(31)14-35(32,33)21-13-30(20-8-3-2-6-19(20)21)12-16-5-4-7-18(24(16)25)17-10-26-27-11-17/h2-11,13H,12,14H2,1H3,(H,26,27)(H,28,29,31)
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4.40E+3n/an/an/an/a



Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL


Assay Description
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 21: 2697-701 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.015
BindingDB Entry DOI: 10.7270/Q2BG2PB2
More data for this
Ligand-Target Pair