BDBM50343189 CHEMBL1773576::N-(6-(2-(N-Ethyl-4-methoxyphenylsulfonamido)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

SMILES CCN(c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1)S(=O)(=O)c1ccc(OC)cc1

InChI Key InChIKey=KHSRJLWEMLJKCX-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343189   

LigandChemical structure of BindingDB Monomer ID 50343189BDBM50343189(N-(6-(2-(N-Ethyl-4-methoxyphenylsulfonamido)pyrimi...)
Affinity DataKi:  62nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50343189BDBM50343189(N-(6-(2-(N-Ethyl-4-methoxyphenylsulfonamido)pyrimi...)
Affinity DataIC50: 262nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50343189BDBM50343189(N-(6-(2-(N-Ethyl-4-methoxyphenylsulfonamido)pyrimi...)
Affinity DataIC50: 305nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed