BDBM50343505 (S)-4-(4-(4-fluorophenyl)-2-(isopropylsulfinyl)-1H-imidazol-5-yl)-N-isopropylpyridin-2-amine::CHEMBL1773499

SMILES CC(C)Nc1cc(ccn1)-c1nc([nH]c1-c1ccc(F)cc1)[S@@](=O)C(C)C

InChI Key InChIKey=LHMWWTJHYWIHMU-MHZLTWQESA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50343505   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50343505((S)-4-(4-(4-fluorophenyl)-2-(isopropylsulfinyl)-1H...)
Affinity DataIC50:  6nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50343505((S)-4-(4-(4-fluorophenyl)-2-(isopropylsulfinyl)-1H...)
Affinity DataIC50:  250nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as suppression of LPS-induced TNF-alpha release by immunosorbent non-radioactive enzyme as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50343505((S)-4-(4-(4-fluorophenyl)-2-(isopropylsulfinyl)-1H...)
Affinity DataIC50:  610nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as suppression of LPS-induced TNF-alpha release by immunosorbent non-radioactive enzyme as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50343505((S)-4-(4-(4-fluorophenyl)-2-(isopropylsulfinyl)-1H...)
Affinity DataIC50:  3nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed