BDBM50344383 6-methyl-2-(thiophen-2-ylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one::CHEMBL1779857

SMILES CN1CCc2nc(ccc2C1=O)C#Cc1cccs1

InChI Key InChIKey=AJDOCVSDQVAAMU-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50344383   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50344383(6-methyl-2-(thiophen-2-ylethynyl)-7,8-dihydro-1,6-...)
Affinity DataKi:  2.17E+3nMAssay Description:Displacement of [3H]-MPEP from human mGluR5 expressed in HEK293 cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50344383(6-methyl-2-(thiophen-2-ylethynyl)-7,8-dihydro-1,6-...)
Affinity DataIC50:  451nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed