BDBM50345529 CHEMBL1784354::N-(1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl)-2-methylpropan-2-yl)-N-hydroxyformamide

SMILES CC(C)(CS(=O)(=O)N1CCN(CC1)c1ccc(F)cc1)N(O)C=O

InChI Key InChIKey=JKTGELXOMXEKJI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50345529   

TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345529(CHEMBL1784354 | N-(1-(4-(4-fluorophenyl)piperazin-...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345529(CHEMBL1784354 | N-(1-(4-(4-fluorophenyl)piperazin-...)
Affinity DataIC50:  92nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345529(CHEMBL1784354 | N-(1-(4-(4-fluorophenyl)piperazin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345529(CHEMBL1784354 | N-(1-(4-(4-fluorophenyl)piperazin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MMP-1 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345529(CHEMBL1784354 | N-(1-(4-(4-fluorophenyl)piperazin-...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed