BDBM50345558 3-(2-(2-methylthiazol-4-yl)ethynyl)-1,5-dibromobenzene::CHEMBL1784604

SMILES Cc1nc(cs1)C#Cc1cc(Br)cc(Br)c1

InChI Key InChIKey=FWXCHAMXBMLXBD-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50345558   

TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345558(3-(2-(2-methylthiazol-4-yl)ethynyl)-1,5-dibromoben...)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345558(3-(2-(2-methylthiazol-4-yl)ethynyl)-1,5-dibromoben...)
Affinity DataIC50:  1.45nMAssay Description:Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed