BDBM50346463 (E)-2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-carbaldehyde oxime::CHEMBL1782958

SMILES Oc1ccc(cc1F)-c1ccc(O)c(CN=O)c1Cl

InChI Key InChIKey=LJPIWESQQAGJHE-UHFFFAOYSA-N

Data  5 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50346463   

TargetEstrogen receptor beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346463((E)-2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-ca...)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]estradiol from human full-length ERbeta receptor by competitive radiometric binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346463((E)-2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-ca...)
Affinity DataKi:  3.74E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346463((E)-2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-ca...)
Affinity DataKi:  5.53E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346463((E)-2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-ca...)
Affinity DataKi:  7.04E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346463((E)-2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-ca...)
Affinity DataKi:  7.27E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346463((E)-2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-ca...)
Affinity DataEC50:  8.40nMAssay Description:Agonist activity at human full-length ERalpha receptor expressed in human HEC1 cells co-expressing (ERE)2-pS2-luc gene assessed as transcriptional ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346463((E)-2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-ca...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human full-length ERbeta receptor expressed in human HEC1 cells co-expressing (ERE)2-pS2-luc gene assessed as transcriptional act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed