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BDBM50347655 CHEMBL1802586

SMILES: CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)N1CCOCC1

InChI Key: InChIKey=NENQLFCGPDUKQZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50347655   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347655
PNG
(CHEMBL1802586)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)N1CCOCC1
Show InChI InChI=1S/C19H19N3O4S/c1-27(24,25)21-14-4-2-13-3-5-18-17(19(23)16(13)10-14)11-15(12-20-18)22-6-8-26-9-7-22/h2-5,10-12,21H,6-9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 46n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
BindingDB Entry DOI: 10.7270/Q2X34ZFZ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347655
PNG
(CHEMBL1802586)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)N1CCOCC1
Show InChI InChI=1S/C19H19N3O4S/c1-27(24,25)21-14-4-2-13-3-5-18-17(19(23)16(13)10-14)11-15(12-20-18)22-6-8-26-9-7-22/h2-5,10-12,21H,6-9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
BindingDB Entry DOI: 10.7270/Q2X34ZFZ
More data for this
Ligand-Target Pair