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BDBM50348109 CHEMBL1800435

SMILES: NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCN(CC(F)(F)F)Cc2c1

InChI Key: InChIKey=YGIVAOFFOBBXPS-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50348109   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive cation channel 3


(Homo sapiens (Human))
BDBM50348109
PNG
(CHEMBL1800435)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCN(CC(F)(F)F)Cc2c1
Show InChI InChI=1S/C22H18ClF3N2S/c23-21-18-6-4-15(10-19(18)29-20(21)11-27)2-1-14-3-5-16-7-8-28(12-17(16)9-14)13-22(24,25)26/h3-6,9-10H,7-8,11-13,27H2
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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.064
BindingDB Entry DOI: 10.7270/Q2DZ08P8
More data for this
Ligand-Target Pair