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BDBM50348355 CHEMBL1800302

SMILES: COc1cc(Cl)c(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc1OC

InChI Key: InChIKey=ZDZGPXIPFIPVAB-FOKLQQMPSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50348355   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348355
PNG
(CHEMBL1800302)
Show SMILES COc1cc(Cl)c(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc1OC
Show InChI InChI=1S/C21H20ClN3O3S/c1-13-8-20(15-6-4-5-7-17(15)24-13)29-12-21(26)25-23-11-14-9-18(27-2)19(28-3)10-16(14)22/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+
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MMDB

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Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair