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BDBM50348367 CHEMBL1800822

SMILES: COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)ccc1F

InChI Key: InChIKey=KSQRUIRRRDSKGA-SSDVNMTOSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50348367   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348367
PNG
(CHEMBL1800822)
Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)ccc1F
Show InChI InChI=1S/C20H18FN3O2S/c1-13-9-19(15-5-3-4-6-17(15)23-13)27-12-20(25)24-22-11-14-7-8-16(21)18(10-14)26-2/h3-11H,12H2,1-2H3,(H,24,25)/b22-11+
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Similars

Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair