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BDBM50348973 CHEMBL1808222

SMILES: COC(=O)c1cccc(Oc2nc[nH]c(=O)c2-c2ccncc2)c1

InChI Key: InChIKey=QKFUPMBPBALCRY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50348973   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin receptor


(Homo sapiens (Human))
BDBM50348973
PNG
(CHEMBL1808222)
Show SMILES COC(=O)c1cccc(Oc2nc[nH]c(=O)c2-c2ccncc2)c1
Show InChI InChI=1S/C17H13N3O4/c1-23-17(22)12-3-2-4-13(9-12)24-16-14(15(21)19-10-20-16)11-5-7-18-8-6-11/h2-10H,1H3,(H,19,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+4n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of recombinant IRK using biotinylated-poly(GT) peptide as substrate after 60 mins


Bioorg Med Chem Lett 21: 4592-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.103
BindingDB Entry DOI: 10.7270/Q2N87B4V
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50348973
PNG
(CHEMBL1808222)
Show SMILES COC(=O)c1cccc(Oc2nc[nH]c(=O)c2-c2ccncc2)c1
Show InChI InChI=1S/C17H13N3O4/c1-23-17(22)12-3-2-4-13(9-12)24-16-14(15(21)19-10-20-16)11-5-7-18-8-6-11/h2-10H,1H3,(H,19,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+4n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of recombinant MET using biotinylated-poly(GT) peptide as substrate after 60 mins


Bioorg Med Chem Lett 21: 4592-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.103
BindingDB Entry DOI: 10.7270/Q2N87B4V
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50348973
PNG
(CHEMBL1808222)
Show SMILES COC(=O)c1cccc(Oc2nc[nH]c(=O)c2-c2ccncc2)c1
Show InChI InChI=1S/C17H13N3O4/c1-23-17(22)12-3-2-4-13(9-12)24-16-14(15(21)19-10-20-16)11-5-7-18-8-6-11/h2-10H,1H3,(H,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+4n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged NPM-ALK using biotinylated-poly(GT) peptide as substrate after 60 mins


Bioorg Med Chem Lett 21: 4592-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.103
BindingDB Entry DOI: 10.7270/Q2N87B4V
More data for this
Ligand-Target Pair