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BDBM50351818 CHEMBL1824438

SMILES: Cc1cccc(n1)-c1nn(CCC(=O)Nc2ccccc2)cc1-c1ccc2nccnc2c1

InChI Key: InChIKey=XZIUCFXXNUZGBF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50351818   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351818
PNG
(CHEMBL1824438)
Show SMILES Cc1cccc(n1)-c1nn(CCC(=O)Nc2ccccc2)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H22N6O/c1-18-6-5-9-23(29-18)26-21(19-10-11-22-24(16-19)28-14-13-27-22)17-32(31-26)15-12-25(33)30-20-7-3-2-4-8-20/h2-11,13-14,16-17H,12,15H2,1H3,(H,30,33)
PDB
MMDB

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B.MOAD
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351818
PNG
(CHEMBL1824438)
Show SMILES Cc1cccc(n1)-c1nn(CCC(=O)Nc2ccccc2)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H22N6O/c1-18-6-5-9-23(29-18)26-21(19-10-11-22-24(16-19)28-14-13-27-22)17-32(31-26)15-12-25(33)30-20-7-3-2-4-8-20/h2-11,13-14,16-17H,12,15H2,1H3,(H,30,33)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 82n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair