BindingDB logo
myBDB logout

BDBM50351907 CHEMBL1821781

SMILES: COc1ccc(Br)cc1Cc1nccc2cc(OC)c(OCCF)cc12

InChI Key: InChIKey=XTNKUKGWUYUIKS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50351907   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50351907
PNG
(CHEMBL1821781)
Show SMILES COc1ccc(Br)cc1Cc1nccc2cc(OC)c(OCCF)cc12
Show InChI InChI=1S/C20H19BrFNO3/c1-24-18-4-3-15(21)9-14(18)10-17-16-12-20(26-8-6-22)19(25-2)11-13(16)5-7-23-17/h3-5,7,9,11-12H,6,8,10H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 872n/an/an/an/an/an/a



Washington University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay


Eur J Med Chem 46: 3986-95 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.072
BindingDB Entry DOI: 10.7270/Q279452C
More data for this
Ligand-Target Pair