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BDBM50353016 CHEMBL1821978

SMILES: NC1CCc2cccc(c2CC1=O)-c1ccccc1

InChI Key: InChIKey=OCPQVXLDVBEGMQ-UHFFFAOYSA-N

Data: 7 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50353016   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50353016
PNG
(CHEMBL1821978)
Show SMILES NC1CCc2cccc(c2CC1=O)-c1ccccc1
Show InChI InChI=1S/C17H17NO/c18-16-10-9-13-7-4-8-14(15(13)11-17(16)19)12-5-2-1-3-6-12/h1-8,16H,9-11,18H2
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PubMed
7n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysis


Bioorg Med Chem 19: 5716-33 (2011)


Article DOI: 10.1016/j.bmc.2011.06.089
BindingDB Entry DOI: 10.7270/Q2805307
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50353016
PNG
(CHEMBL1821978)
Show SMILES NC1CCc2cccc(c2CC1=O)-c1ccccc1
Show InChI InChI=1S/C17H17NO/c18-16-10-9-13-7-4-8-14(15(13)11-17(16)19)12-5-2-1-3-6-12/h1-8,16H,9-11,18H2
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PC sid
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Article
PubMed
7n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN assessed as decrease in p-nitroanilide release using L-leucine-p-nitroanilide as substrate by spectrophotometric ana...


Bioorg Med Chem 23: 3192-207 (2015)


Article DOI: 10.1016/j.bmc.2015.04.066
BindingDB Entry DOI: 10.7270/Q2Z321DW
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50353016
PNG
(CHEMBL1821978)
Show SMILES NC1CCc2cccc(c2CC1=O)-c1ccccc1
Show InChI InChI=1S/C17H17NO/c18-16-10-9-13-7-4-8-14(15(13)11-17(16)19)12-5-2-1-3-6-12/h1-8,16H,9-11,18H2
PDB

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PC sid
UniChem

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Article
PubMed
7n/an/an/an/an/an/an/an/a



Universit£ de Haute-Alsace

Curated by ChEMBL


Assay Description
Inhibition of pig APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectriphotometric analysis


Bioorg Med Chem 21: 2135-44 (2013)


Article DOI: 10.1016/j.bmc.2012.12.038
BindingDB Entry DOI: 10.7270/Q2CZ38J9
More data for this
Ligand-Target Pair
Aminopeptidase N


(Mus musculus)
BDBM50353016
PNG
(CHEMBL1821978)
Show SMILES NC1CCc2cccc(c2CC1=O)-c1ccccc1
Show InChI InChI=1S/C17H17NO/c18-16-10-9-13-7-4-8-14(15(13)11-17(16)19)12-5-2-1-3-6-12/h1-8,16H,9-11,18H2
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10n/an/an/an/an/an/an/an/a



Universit£ de Haute-Alsace

Curated by ChEMBL


Assay Description
Inhibition of mouse APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectriphotometric analysis


Bioorg Med Chem 21: 2135-44 (2013)


Article DOI: 10.1016/j.bmc.2012.12.038
BindingDB Entry DOI: 10.7270/Q2CZ38J9
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50353016
PNG
(CHEMBL1821978)
Show SMILES NC1CCc2cccc(c2CC1=O)-c1ccccc1
Show InChI InChI=1S/C17H17NO/c18-16-10-9-13-7-4-8-14(15(13)11-17(16)19)12-5-2-1-3-6-12/h1-8,16H,9-11,18H2
PDB

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11n/an/an/an/an/an/an/an/a



Universit£ de Haute-Alsace

Curated by ChEMBL


Assay Description
Inhibition of human APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectriphotometric analysis


Bioorg Med Chem 21: 2135-44 (2013)


Article DOI: 10.1016/j.bmc.2012.12.038
BindingDB Entry DOI: 10.7270/Q2CZ38J9
More data for this
Ligand-Target Pair
Bacterial leucyl aminopeptidase


(Vibrio proteolyticus)
BDBM50353016
PNG
(CHEMBL1821978)
Show SMILES NC1CCc2cccc(c2CC1=O)-c1ccccc1
Show InChI InChI=1S/C17H17NO/c18-16-10-9-13-7-4-8-14(15(13)11-17(16)19)12-5-2-1-3-6-12/h1-8,16H,9-11,18H2
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UniChem

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Article
PubMed
2.80E+4n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of Aeromonas proteolytica aminopeptidase using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysis


Bioorg Med Chem 19: 5716-33 (2011)


Article DOI: 10.1016/j.bmc.2011.06.089
BindingDB Entry DOI: 10.7270/Q2805307
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM50353016
PNG
(CHEMBL1821978)
Show SMILES NC1CCc2cccc(c2CC1=O)-c1ccccc1
Show InChI InChI=1S/C17H17NO/c18-16-10-9-13-7-4-8-14(15(13)11-17(16)19)12-5-2-1-3-6-12/h1-8,16H,9-11,18H2
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KEGG

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B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney cytosolic leucine aminopeptidase using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysis


Bioorg Med Chem 19: 5716-33 (2011)


Article DOI: 10.1016/j.bmc.2011.06.089
BindingDB Entry DOI: 10.7270/Q2805307
More data for this
Ligand-Target Pair