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BDBM50353665 CHEMBL1830470

SMILES: CC(C)(C)c1ccc(CN2CCN(CC2)C(=O)CCc2cc(-c3ccc(cc3)C(F)(F)F)n(n2)-c2ccccc2)cc1

InChI Key: InChIKey=HPPIMWYSQVFHBZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50353665   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50353665
PNG
(CHEMBL1830470)
Show SMILES CC(C)(C)c1ccc(CN2CCN(CC2)C(=O)CCc2cc(-c3ccc(cc3)C(F)(F)F)n(n2)-c2ccccc2)cc1
Show InChI InChI=1S/C34H37F3N4O/c1-33(2,3)27-13-9-25(10-14-27)24-39-19-21-40(22-20-39)32(42)18-17-29-23-31(41(38-29)30-7-5-4-6-8-30)26-11-15-28(16-12-26)34(35,36)37/h4-16,23H,17-22,24H2,1-3H3
PDB
MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



Gazi University

Curated by ChEMBL


Assay Description
Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187


Eur J Med Chem 46: 5021-33 (2011)


Article DOI: 10.1016/j.ejmech.2011.08.009
BindingDB Entry DOI: 10.7270/Q2445MVS
More data for this
Ligand-Target Pair