BDBM50353847 CHEMBL1831157::US9604926, Compound CM-360::US9724435, Compound CM-360

SMILES COc1cc2CCN(CCCCn3ccc4ccccc34)Cc2cc1OC

InChI Key InChIKey=HDRNEAMIVJIRBJ-UHFFFAOYSA-N

Data  5 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50353847   

TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM50353847(CHEMBL1831157 | US9604926, Compound CM-360 | US972...)
Affinity DataKi:  0.210nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM50353847(CHEMBL1831157 | US9604926, Compound CM-360 | US972...)
Affinity DataKi:  0.210nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM50353847(CHEMBL1831157 | US9604926, Compound CM-360 | US972...)
Affinity DataKi:  73.2nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Mississippi

US Patent
LigandPNGBDBM50353847(CHEMBL1831157 | US9604926, Compound CM-360 | US972...)
Affinity DataKi:  73.2nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Mississippi

US Patent
LigandPNGBDBM50353847(CHEMBL1831157 | US9604926, Compound CM-360 | US972...)
Affinity DataKi:  141nMAssay Description:Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat brain membrane after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50353847(CHEMBL1831157 | US9604926, Compound CM-360 | US972...)
Affinity DataEC50:  6.09E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK-MDR1 cells assessed as calcein cell accumulation after 30 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed