BDBM50354578 BUPRENORPHINE::US10752592, Compound buprenorphine::US11534436, Compound buprenorphine::US9315514, Buprenorphine
SMILES CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45
InChI Key InChIKey=RMRJXGBAOAMLHD-CTAPUXPBSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 49 hits for monomerid = 50354578
Affinity DataKi: 0.0400nM ΔG°: -14.2kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...More data for this Ligand-Target Pair
Affinity DataKi: 0.0700nMAssay Description:Binding affinity to human cloned kappa opioid receptor expressed in HEK293 cells by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0890nMAssay Description:Displacement of [3H]diprenorphine from recombinant human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0890nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.0900nMAssay Description:Binding affinity to human cloned mu opioid receptor expressed in CHO cells by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nM ΔG°: -14.1kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Displacement of [3H]DAMGO from MOR in Hartley guinea pig membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataKi: 0.480nMAssay Description:Displacement of [3H]diprenorphine from rat delta opioid receptor expressed in rat C6 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.480nMAssay Description:Displacement of [3H]diprenorphine from rat delta opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Bath
Curated by ChEMBL
University Of Bath
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Agonist activity at kappa opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity to human cloned delta opioid receptor expressed in CHO cells by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]DAMGO from MOR in guinea pig brain membraneMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Binding affinity towards mu opioid receptor in guinea pig brain membranes using [3H]- DAMGO as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]-DAMGO from human mu opioid receptor transfected in CHO cells after 60 mins by beta-plate liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Bath
Curated by ChEMBL
University Of Bath
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Binding affinity towards kappa opioid receptor in guinea pig brain membranes using [3H]- U-69,593 as radioligandMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Bath
Curated by ChEMBL
University Of Bath
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]U69593 from KOR in guinea pig brain membraneMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Binding affinity towards delta opioid receptor in guinea pig brain membranes using [3H]- CI-DPDPE as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-U69,593 from human kappa opioid receptor transfected in CHO cells after 60 mins by beta-plate liquid scintillation counting anal...More data for this Ligand-Target Pair
Affinity DataKi: 6.10nMAssay Description:Displacement of [3H]-DPDPE from human delta opioid receptor transfected in CHO cells after 60 mins by beta-plate liquid scintillation counting analys...More data for this Ligand-Target Pair
Affinity DataKi: 77nMAssay Description:Displacement of [3H]-N/OFQ from human nociceptin opioid receptor transfected in CHO cells after 60 mins by beta-plate liquid scintillation counting a...More data for this Ligand-Target Pair
Affinity DataKi: 212nMAssay Description:Displacement of [3H]nociceptin from human NOP receptor expressed in HEK293 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 212nMAssay Description:Displacement of [3H]-N/OFQ from recombinant nociceptin opioid receptor (unknown origin) expressed in HEK cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.450nMpH: 7.4 T: 2°CAssay Description:[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-house from a cell line expressing recombin...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human mu opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by beta-plate l...More data for this Ligand-Target Pair
TargetDelta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1(Rattus norvegicus (rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 0.410nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1(Rattus norvegicus (rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 0.440nMAssay Description:Inhibition of [3H]naloxone binding to rat brain membrane with 100 mM NaCl.More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:The EC50 and Imax for μ opioid receptors was determined using a [35S]GTPγS binding assay. This assay measures the functional properties of ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.450nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescen...More data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataEC50: 0.560nMpH: 7.4 T: 2°CAssay Description:Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataIC50: 0.450nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataEC50: 1.48E+3nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cell membranes assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 21nMAssay Description:Agonist activity at MOR in guinea pig vas deferensMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Bath
Curated by ChEMBL
University Of Bath
Curated by ChEMBL
Affinity DataEC50: 21nMAssay Description:Agonist activity at KOR in guinea pig vas deferensMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Reverse Proteomics Research Institute
Curated by ChEMBL
Reverse Proteomics Research Institute
Curated by ChEMBL
Affinity DataIC50: 7.59E+3nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
Affinity DataEC50: 2.30nMAssay Description:Activity was evaluated in human mu opioid receptors transfected with CHO cells by [35S]GTP-gamma-S, assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Bath
Curated by ChEMBL
University Of Bath
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Agonist activity at kappa opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at rat mu opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.450nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair