BindingDB PrimarySearch

BDBM50355501 INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147::US20240140952, Compound Ruxolitinib

SMILES: c1c[nH]c2c1c(ncn2)c3cnn(c3)[C@H](CC#N)C4CCCC4

InChI Key: InChIKey=HFNKQEVNSGCOJV-UHFFFAOYSA-N

Data: 12 KI 141 IC50 447 Kd 6 EC50

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 634 hits for monomerid = 50355501
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [811-1124] (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	200	n/a	n/a	n/a	n/a	7.5	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [888-1187] (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [811-1124] (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [888-1187] (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	194	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	677	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.0560	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.0560	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	487	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	428	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	428	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Mouse)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	186	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50355501 (RUXOLITINIB PHOSPHATE \| INCB-018424 \| RUXOLITINIB ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair

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