BindingDB PrimarySearch

BDBM50357312 IBRUTINIB::PCI-32765::US10124003, Ref. Ex. Compound 1::US10711006, Compound Ibrutinib::US10793575, Example ibrutinib::US10835536, Ref. Ex. Comp 1::US10919899, Ibrutinib::US11078206, Example Ibrutinib::US11186578, Example Ibrutinib::US11339167, Example Ibrutinib::US11407754, Example Ibrutinib::US20230364079, Example Ibrutinib::US20240059694, Compound Ibrutinib::US20240139326, Compound Ibrutinib::US9108973, Ref 1::US9181263, 1::US9278100, 1

SMILES: Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C

InChI Key: InChIKey=XYFPWWZEPKGCCK-UHFFFAOYSA-N

Data: 3 KI 373 IC50 18 Kd 4 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 439 hits for monomerid = 50357312
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Epidermal growth factor receptor (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.5	25
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Tyrosine-protein kinase BTK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.75	n/a	n/a	n/a	n/a	7.4	n/a
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TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	75.3	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 2 (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 2 (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	280	n/a	n/a	n/a	n/a	7.5	25
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
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Cytoplasmic tyrosine-protein kinase BMX (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Tec (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	77.8	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	263	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fgr (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	95.6	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase HCK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lyn (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	16.2	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Yes (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	86.1	n/a	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 6 (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase CSK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fer (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK3 (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase SYK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Cytoplasmic tyrosine-protein kinase BMX (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase Tec (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	77.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase Blk (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	263	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase Fgr (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	95.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	16.2	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase Yes (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	86.1	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Protein-tyrosine kinase 6 (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase CSK (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fer (Human)	BDBM50357312 (IBRUTINIB \| US9181263, 1 \| US9108973, Ref 1 \| US92...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
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