BDBM50357610 CHEMBL1915644

SMILES CNC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccncc21

InChI Key InChIKey=IXLHWDDKCRTAAT-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50357610   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357610(CHEMBL1915644)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 30 uM [ATP]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357610(CHEMBL1915644)
Affinity DataIC50:  16nMAssay Description:Inhibition of PIM1 using KKRNRTLTV as substrate by millipore assay in the presence of 90 uM [ATP]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357610(CHEMBL1915644)
Affinity DataIC50:  5nMAssay Description:Inhibition of PIM2 by millipore assay in the presence of 15 uM [ATP]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357610(CHEMBL1915644)
Affinity DataEC50:  2.60E+3nMAssay Description:Inhibition of FLT3 phosphorylation at Tyr591 in human MV-4-11 cells assessed as phospho-FLT3 level after 4 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357610(CHEMBL1915644)
Affinity DataIC50:  23nMAssay Description:Inhibition of FLT3 using EAIYAAPFAKKK as substrate by radiometric assay in the presence of 200 uM [ATP]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357610(CHEMBL1915644)
Affinity DataEC50:  1.02E+3nMAssay Description:Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357610(CHEMBL1915644)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357610(CHEMBL1915644)
Affinity DataIC50:  367nMAssay Description:Inhibition of PIM3 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 155 uM [ATP]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed