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BDBM50358783 CHEMBL1346011

SMILES: Oc1ccc(C(=O)COc2ccccc2Br)c(O)c1

InChI Key: InChIKey=LDDWVJINSMJWQT-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50358783   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50358783
PNG
(CHEMBL1346011)
Show SMILES Oc1ccc(C(=O)COc2ccccc2Br)c(O)c1
Show InChI InChI=1S/C14H11BrO4/c15-11-3-1-2-4-14(11)19-8-13(18)10-6-5-9(16)7-12(10)17/h1-7,16-17H,8H2
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at human muscarinic acetylcholine receptor 4 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-in...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50358783
PNG
(CHEMBL1346011)
Show SMILES Oc1ccc(C(=O)COc2ccccc2Br)c(O)c1
Show InChI InChI=1S/C14H11BrO4/c15-11-3-1-2-4-14(11)19-8-13(18)10-6-5-9(16)7-12(10)17/h1-7,16-17H,8H2
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.40E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as potentiation of EC20 glutamate-induced c...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50358783
PNG
(CHEMBL1346011)
Show SMILES Oc1ccc(C(=O)COc2ccccc2Br)c(O)c1
Show InChI InChI=1S/C14H11BrO4/c15-11-3-1-2-4-14(11)19-8-13(18)10-6-5-9(16)7-12(10)17/h1-7,16-17H,8H2
UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.10E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu4 receptor expressed in human HEK293 cells co-expressing GIRK potassium channels assessed as potentiation o...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50358783
PNG
(CHEMBL1346011)
Show SMILES Oc1ccc(C(=O)COc2ccccc2Br)c(O)c1
Show InChI InChI=1S/C14H11BrO4/c15-11-3-1-2-4-14(11)19-8-13(18)10-6-5-9(16)7-12(10)17/h1-7,16-17H,8H2
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at human muscarinic acetylcholine receptor 1 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-in...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair