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BDBM50358894 CHEMBL1923570

SMILES: COc1ccc(Nc2ncc3ccc(-c4ccccc4OC)n3n2)cc1

InChI Key: InChIKey=LHHGPWPUBLDJPL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50358894   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50358894
PNG
(CHEMBL1923570)
Show SMILES COc1ccc(Nc2ncc3ccc(-c4ccccc4OC)n3n2)cc1
Show InChI InChI=1S/C20H18N4O2/c1-25-16-10-7-14(8-11-16)22-20-21-13-15-9-12-18(24(15)23-20)17-5-3-4-6-19(17)26-2/h3-13H,1-2H3,(H,22,23)
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Similars

Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Cephalon Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK2 using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate after 20 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7325-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.032
BindingDB Entry DOI: 10.7270/Q2GT5NM2
More data for this
Ligand-Target Pair