BDBM50360305 CHEMBL409855::US9149492, Beauveriolide III

SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1

InChI Key InChIKey=VEELKRGSLCNVAR-QVZGIDAOSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50360305   

TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Dartmouth College

US Patent
LigandPNGBDBM50360305(CHEMBL409855 | US9149492, Beauveriolide III)
Affinity DataIC50:  900nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSterol O-acyltransferase 2(Homo sapiens (Human))
Dartmouth College

US Patent
LigandPNGBDBM50360305(CHEMBL409855 | US9149492, Beauveriolide III)
Affinity DataIC50: >2.00E+4nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Dartmouth College

US Patent
LigandPNGBDBM50360305(CHEMBL409855 | US9149492, Beauveriolide III)
Affinity DataIC50:  410nMAssay Description:Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Chlorocebus aethiops)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50360305(CHEMBL409855 | US9149492, Beauveriolide III)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of African green monkey SOAT1 expressed in CHO cells assessed as decrease in [14C]CE synthesis from [14C]oleic acid after 6 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Chlorocebus aethiops)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50360305(CHEMBL409855 | US9149492, Beauveriolide III)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of African green monkey SOAT1 isolated from CHO cell microsomes assessed as decrease in [14C]CE synthesis from [14C]oleic acid after 5 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 2(Chlorocebus aethiops)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50360305(CHEMBL409855 | US9149492, Beauveriolide III)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of African green monkey SOAT2 isolated from CHO cell microsomes assessed as decrease in [14C]CE synthesis from [14C]oleic acid after 5 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 2(Chlorocebus aethiops)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50360305(CHEMBL409855 | US9149492, Beauveriolide III)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of African green monkey SOAT2 expressed in CHO cells assessed as decrease in [14C]CE synthesis from [14C]oleic acid after 6 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed