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BDBM50362079 CHEMBL1940263

SMILES: COc1cccc(c1)S(=O)(=O)NCc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1

InChI Key: InChIKey=DTHOTEZEHTUKLO-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50362079   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50362079
PNG
(CHEMBL1940263)
Show SMILES COc1cccc(c1)S(=O)(=O)NCc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C24H23N3O6S/c1-30-18-5-4-6-19(11-18)34(28,29)27-14-16-7-9-17(10-8-16)33-24-20-12-22(31-2)23(32-3)13-21(20)25-15-26-24/h4-13,15,27H,14H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 phosphorylation by cell based assay


Bioorg Med Chem Lett 22: 262-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.019
BindingDB Entry DOI: 10.7270/Q24F1R6H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50362079
PNG
(CHEMBL1940263)
Show SMILES COc1cccc(c1)S(=O)(=O)NCc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C24H23N3O6S/c1-30-18-5-4-6-19(11-18)34(28,29)27-14-16-7-9-17(10-8-16)33-24-20-12-22(31-2)23(32-3)13-21(20)25-15-26-24/h4-13,15,27H,14H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of FLT3 phosphorylation by cell based assay


Bioorg Med Chem Lett 22: 262-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.019
BindingDB Entry DOI: 10.7270/Q24F1R6H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R)


(Homo sapiens (Human))
BDBM50362079
PNG
(CHEMBL1940263)
Show SMILES COc1cccc(c1)S(=O)(=O)NCc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C24H23N3O6S/c1-30-18-5-4-6-19(11-18)34(28,29)27-14-16-7-9-17(10-8-16)33-24-20-12-22(31-2)23(32-3)13-21(20)25-15-26-24/h4-13,15,27H,14H2,1-3H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
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n/an/a>1.00E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF1R phosphorylation by cell based assay


Bioorg Med Chem Lett 22: 262-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.019
BindingDB Entry DOI: 10.7270/Q24F1R6H
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50362079
PNG
(CHEMBL1940263)
Show SMILES COc1cccc(c1)S(=O)(=O)NCc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C24H23N3O6S/c1-30-18-5-4-6-19(11-18)34(28,29)27-14-16-7-9-17(10-8-16)33-24-20-12-22(31-2)23(32-3)13-21(20)25-15-26-24/h4-13,15,27H,14H2,1-3H3
PDB
MMDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta phosphorylation by cell based assay


Bioorg Med Chem Lett 22: 262-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.019
BindingDB Entry DOI: 10.7270/Q24F1R6H
More data for this
Ligand-Target Pair