BDBM50362583 CHEMBL1938871

SMILES OC(=O)Cn1nnc(n1)-c1cc(no1)N1CC2CN(CC2C1)c1cc(F)ccc1Cl

InChI Key InChIKey=ZMSGLYQOQFYEBI-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50362583   

TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362583(CHEMBL1938871)
Affinity DataIC50:  24nMAssay Description:Inhibition of SCD-1 activity in rat liver microsomes assessed as reduction in [1-14C] stearoyl CoA desaturation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362583(CHEMBL1938871)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of SCD-1 activity in organic anion transporting polypeptides-deficient human HepG2 cells assessed as reduction in [1-14C] stearoyl CoA des...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362583(CHEMBL1938871)
Affinity DataIC50:  198nMAssay Description:Inhibition of SCD-1 activity in rat hepatocytes expressing organic anion transporting polypeptides assessed as reduction in [1-14C] stearoyl CoA desa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase 5(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362583(CHEMBL1938871)
Affinity DataIC50:  242nMAssay Description:Inhibition of human SCD-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA 6-desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362583(CHEMBL1938871)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human delta-6 desaturase activity in human HepG2 cells using [1-14C]-stearic acid tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362583(CHEMBL1938871)
Affinity DataIC50:  18nMAssay Description:Inhibition of mouse SCD-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362583(CHEMBL1938871)
Affinity DataIC50:  27nMAssay Description:Inhibition of human SCD-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA (8-3)-desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362583(CHEMBL1938871)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human delta-5 desaturase activity in human HepG2 cells using [1-14C]-stearic acid tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed