BDBM50362781 1256580-46-7::AF802::Alecensa::Alectinib::CH5424802::CHEMBL1738797::US10851092, Example Alectinib::US11066363, Compound Alectinib::US12129258, Example Alectinib::US20240246927, Control group::US9126931, 366

SMILES: CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N1CCOCC1

InChI Key: InChIKey=KDGFLJKFZUIJMX-UHFFFAOYSA-N

Data: 5 KI  66 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 71 hits for monomerid = 50362781   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	133	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	597	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	724	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	201	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
H-2 class II histocompatibility antigen gamma chain (Mus musculus)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
H-2 class II histocompatibility antigen gamma chain (Mus musculus)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	695	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	811	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
SRSF protein kinase 2 (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	28.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4 (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	195	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4 (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50362781 (CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair