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BDBM50365235 CHEMBL1956277

SMILES: Cc1cc(Nc2cccc(Cl)c2)n2nc(nc2n1)C1CC1

InChI Key: InChIKey=YIEMJPVAZNEAGQ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50365235   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50365235
PNG
(CHEMBL1956277)
Show SMILES Cc1cc(Nc2cccc(Cl)c2)n2nc(nc2n1)C1CC1
Show InChI InChI=1S/C15H14ClN5/c1-9-7-13(18-12-4-2-3-11(16)8-12)21-15(17-9)19-14(20-21)10-5-6-10/h2-4,7-8,10,18H,5-6H2,1H3
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Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay


J Med Chem 54: 5540-61 (2011)


Article DOI: 10.1021/jm200592f
BindingDB Entry DOI: 10.7270/Q21N81M0
More data for this
Ligand-Target Pair