BDBM50365718 CHEMBL1955991

SMILES: FC(F)(F)c1cccnc1-c1ccc2[nH]c(C=CC3CCCCC3)nc2c1

InChI Key: InChIKey=TWWBGTVSOOPPOD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50365718   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential M8 protein (TRPM8) (Canis lupus familiaris (Dog))	BDBM50365718 (CHEMBL1955991) Show SMILES FC(F)(F)c1cccnc1-c1ccc2[nH]c(C=CC3CCCCC3)nc2c1 Show InChI InChI=1S/C21H20F3N3/c22-21(23,24)16-7-4-12-25-20(16)15-9-10-17-18(13-15)27-19(26-17)11-8-14-5-2-1-3-6-14/h4,7-14H,1-3,5-6H2,(H,26,27)	KEGG UniProtKB/TrEMBL GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium flux by FLIPR assay				Bioorg Med Chem Lett 22: 1903-7 (2012) Article DOI: 10.1016/j.bmcl.2012.01.060 BindingDB Entry DOI: 10.7270/Q290248D
					More data for this Ligand-Target Pair