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BDBM50365718 CHEMBL1955991

SMILES: FC(F)(F)c1cccnc1-c1ccc2[nH]c(C=CC3CCCCC3)nc2c1

InChI Key: InChIKey=TWWBGTVSOOPPOD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50365718   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50365718
PNG
(CHEMBL1955991)
Show SMILES FC(F)(F)c1cccnc1-c1ccc2[nH]c(C=CC3CCCCC3)nc2c1
Show InChI InChI=1S/C21H20F3N3/c22-21(23,24)16-7-4-12-25-20(16)15-9-10-17-18(13-15)27-19(26-17)11-8-14-5-2-1-3-6-14/h4,7-14H,1-3,5-6H2,(H,26,27)
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium flux by FLIPR assay


Bioorg Med Chem Lett 22: 1903-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.060
BindingDB Entry DOI: 10.7270/Q290248D
More data for this
Ligand-Target Pair